CMV retinitis

Causes and Risks:
Infection with CMV is very common. Eighty percent of adults have antibodies (an indication of previous infection) to it in their blood. Usually CMV produces no symptoms, but serious CMV infections can occur in people with impaired immunity , such as those with AIDS , organ transplant and bone marrow transplant recipients, and people receiving chemotherapy or other immunosuppressive treatments.

CMV retinitis occurs in approximately 25% of AIDS patients and can become a sight-threatening infection. Retinitis usually begins in one eye, but progression to the other eye is common. Systemic CMV infection may also be present. Even with continuous treatment, progression of the disease to blindness can occur. This may result from viral resistance to drugs, or from continued deterioration of the person's immune system.

Prevention:
Because symptomatic CMV infection normally occurs only in immune compromised individuals avoiding the primary cause of immune deficiency, AIDS , will prevent CMV infection. Individuals undergoing chemotherapy , taking anti-rejection medications for transplant and cortisone therapy should have reverse isolation during the acute phase and avoid high exposure until immune function returns to normal.

Symptoms:



Signs and Tests:



Treatment:
The objective of treatment is to prevent progression of the disease, which can lead to blindness . Therapy must be continued indefinitely, or until blindness occurs. The antiviral medications cytovene or foscarnet administered intravenously, indefinitely, or as long as the patient tolerates it.

Prognosis:
Progression of the disease is common, even when therapy continues. Antiviral medications stop the replication of the virus but do not destroy it. CMV is in itself immunosuppressive and may worsen the symptoms of other causes of immunosuppression .

Complications:



Call Your Healthcare Provider:
Call your health care provider if symptoms worsen or do not improve with treatment.

Call your health care provider if new symptoms develop.


This is an illustration of a cross-section and frontal view of the eye.