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Histoplasmosis 
This is an illustration of the major features of the lungs and bronchial tree. The inset is of the alveoli. They are the microscopic blood vessel-lined sacks in which oxygen and carbon dioxide gas are exchanged.
Erythema nodosum consists of red to reddish purple hard (indurated) nodules which are painful to the slightest touch. These are most commonly seen on the shins (as pictured), but may occur on the thighs or elsewhere. They often occur in association with a group of widely varied diseases such as tuberculosis (TB), sarcoidosis, coccidioidomycosis, SLE, other fungal infections, and some drugs.
Erythema nodosum usually occurs in association with specific infections, inflammatory conditions, or medications. It consists of painful, hot, red skin lumps, usually over the shins. People with erythema nodosum should be evaluated for other disease processes.
This is a skin lesion resulting from disseminated histoplasmosis. Histoplasmosis occurs most frequently as a lung infection, however it can infect the skin or become distributed (disseminated) to internal organs.
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